The mechanisms of action of disease-modifying antirheumatic drugs: A review with emphasis on macrophage signal transduction and the induction of proinflammatory cytokines

The mechanisms of action of disease-modifying antirheumatic drugs: A review with emphasis on macrophage signal transduction and the induction of proinflammatory cytokines

Source :

• General Pharmacology [ 0306-3623 ] ; 1997.

English descriptors

• Teeft :
  • Activation, Activator, Acute phase reactants, Agents actions, Antimalarial, Antimalarial compounds, Antirheumatic, Antirheumatic drugs, Antirheumatic gold compounds, Arachidonate, Arachidonate release, Arachidonic, Arachidonic acid, Arend, Arthritis, Arthritis rheum, Articular, Assay, Auranofin, Aurothioglucose, Aurothiomalate, Azathioprine, Betts, Bimodal effect, Bioassay, Biochem, Biol, Biophys, Blood monocytes, Bondeson, Calcium ionophore, Cartilage, Cartilage destruction, Cascade, Cell membrane, Cell types, Chang, Chem, Chemotaxis, Chloroquine, Clin, Clinical intuition, Clinical response, Clinical studies, Compound, Cyclooxygenase, Cyclooxygenase inhibition, Cyclosporin, Cytokine, Cytokine production, Danis, Dayer, Diacylglycerol, Dinarello, Disease activity, Dmards, Duff, Eicosanoid, Eicosanoid formation, Elisa, Elisa study, Endothelial cells, Epidermal, Epidermal growth factor, Ester, Febs lett, Feldmann, Felson, Fibroblast, Froscio, Gold complexes, Gold compound, Gold compounds, Gold sodium thiomalate, Growth factor, Human blood monocytes, Human macrophages, Human monocytes, Human neutrophils, Human synovial cells, Hurst, Hydrophilic gold compounds, Hydroxychloroquine, Immunol, Important role, Inducer, Induction, Inflammation, Inflammatory, Inflammatory cells, Inhibition, Inhibitor, Inhibitory, Inhibitory effect, Inositol, Interleukin, Intracellular, Isoenzymes, Joint destruction, Kinase, Leukocyte, Leukocyte biol, Leukotriene, Liposomal methotrexate, Lipoxygenase, Lipoxygenase metabolites, Lipoxygenase pathways, Lipoxygenase products, Lund university, Lysosomal, Macrophage, Macrophage arachidonate release, Macrophage signal transduction, Maini, Many rheumatologists, Matsubara, Mediator, Metabolism, Methotrexate, Monoclonal antibodies, Monocyte, Monocyte chemoattractant protein, Mononuclear, Mononuclear cells, Mononuclear phagocytes, Mouse macrophages, Mrna, Mrna level, Murine, Necrosis, Neutrophil, Neutrophil chemotaxis, Nielsen, Nsaid, Other studies, Other transcription factors, Parente, Particular interest, Pathway, Peripheral blood, Peripheral blood monocytes, Peritoneal macrophages, Phagocyte, Pharmac, Phorbol, Phorbol ester, Phospholipase, Phospholipid, Phosphorylate, Phosphorylated, Phosphorylation, Pivotal, Pivotal role, Placebo, Platelet, Potent inhibitor, Potentiating effect, Proinflammatory, Proinflammatory cytokines, Prostaglandin, Prostanoid, Prostanoid formation, Prostanoid synthesis, Protein, Protein kinase, Protein kinases, Quinacrine, Receptor, Receptor antagonist, Receptor tyrosine kinase, Receptor tyrosine kinases, Rheum, Rheumatic diseases, Rheumatoid, Rheumatoid arthritis, Rheumatoid arthritis patients, Rheumatoid inflammation, Rheumatoid synovial fluid, Rheumatol, Rheumatology, Scand, Serum levels, Several studies, Side effects, Signal transduction, Similar concentrations, Soluble receptor, Stimulatory effect, Sulfapyridine, Sulfasalazine, Sulphasalazine, Sundler, Superoxide, Symons, Synovial, Synovial cells, Synovial fluid, Target cells, Tenidap, Therapeutic concentrations, Transcription, Transcription factor, Transcription factors, Transduction, Trends biochem, Tumor necrosis factor, Tyrosine, Tyrosine kinase receptor, Tyrosine kinases, Tyrosine phosphorylation, Various cell types, Various stimuli, Wijkander, Zymosan, Zymosan particles.

Abstract

• https://api.istex.fr/ark:/67375/6H6-VXN65VDF-4/fulltext.pdf

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